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Supplementary Figure 8 from TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

Year: 2023
Type: supplementary-materials
Abstract: PDF file - 109K, TMEM16A inhibition with T16A-inh01 (A01) alone or in combination with the MEK/ERK inhibitor UO126 leads to decreased tumor cell viability in vitro. UM-SCC1 and T24 cells were treated with increasing concentrations of A01. A dose dependent reduction in cell viability was observed (A, B *P<0.05, **P<0.01, ***P<0.001). Additionally, treatment of SCC1 and T24 cells with TMEM16A shRNA led to a decrease in cell viability that in combination with inhibition of ERK1/2 had an additive effect (C, D; mean � SEM; n=4, *P<0.05, **P<0.01). The chemical structure of AO1 is shown in panel E.
DOI: 10.1158/0008-5472.22391841.v1
Authors: Umamaheswar Duvvuri, Daniel J. Shiwarski, Dong Xiao, Carol Bertrand, Xin Huang, Robert S. Edinger, Jason R. Rock, Brian D. Harfe, Brian J. Henson, Karl Kunzelmann, Rainer Schreiber, Raja S. Seethala, Ann Marie Egloff, Xing Chen, Vivian W. Lui, Jennifer R. Grandis, Susanne M. Gollin
Language: English
Open Access status: gold
OpenAlex ID: W4361833744
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