Supplemental data from YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2–EGFR Signaling Axis
Year: 2023
Type: supplementary-materials
Abstract: Supplemental figures, methods and tables. Figure S1 (related to Figure 1): YAP activity is required for NF2-null Schwann cell proliferation. Figure S2 (related to Figure 2): YAP is required for colony formation in vitro and tumor growth in vivo. Figure S3 (related to Figure 4): COX-2 activity is required for NF2-null Schwann cell growth. Figure S4 (related to Figure 5): SU6656 treatment suppresses EGFR activation. (A&B) Figure S5 (related to Figure 6): YAP activity increases the expression of COX-2 and AREG. Figure S6: Schematic model for the proposed role of YAP in NF2-null schwannoma cells. Table S1: Sequences of siRNAs Table S2: Primer Sequences for RT-PCR
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361834479