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Supplementary Figure S4 from Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig. S4. TUNEL and Ki67 staining for detection of proliferating and apoptotic cells, respectively. A. TUNEL and Ki67 stained sections of four OVCAR5-shHuR and four OVCAR5-shCtrl ovarian xenografts. Areas of Ki67- cells are delineated with a white dotted line. B. In vitro staining of parental OVCAR5 cells, OVCAR5-shCtrl cells and OVCAR5-shHuR cells. Ki67+ cells and DAPI-stained cells were counted in three 1.4mm2 fields to determine % Ki67+ cells. * indicates p = 0.003 between parental and shHuR cells. DAPI stains nuclei in panels A and B. White bar = 50 mm.
DOI: 10.1158/0008-5472.22410704
Authors: Yu-Hung Huang, Weidan Peng, Narumi Furuuchi, Jacquelyn Gerhart, Kelly Rhodes, Neelanjan Mukherjee, Masaya Jimbo, Gregory E. Gonye, Jonathan R. Brody, Robert C. Getts, Janet A. Sawicki
Language: English
Open Access status: gold
OpenAlex ID: W4361237601
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