Data from Integrated Genomic Characterization of the Human Immunome in Cancer
Year: 2023
Type: other
Abstract: Alterations in immune-related pathways are common hallmarks of cancer. A comprehensive understanding of how cancer mutations rewire immune signaling networks and functional output across cancer types is instrumental to realize the full potential of immunotherapy. Here, we systematically interrogated somatic mutations involved in immune signaling that alter immune responses in patients with cancer. To do so, we developed a Network-based Integrative model to Prioritize Potential immune respondER genes (NIPPER). Identified mutations were enriched in essential protein domains and genes identified by NIPPER were associated with responsiveness to multiple immunotherapy modalities. These genes were used to devise an interactome network propagation framework integrated with drug-associated gene signatures to identify potential immunomodulatory drug candidates. Together, our systems-level analysis results help interpret the heterogeneous immune responses among patients and serve as a resource for future functional studies and targeted therapeutics. Significance: This study demonstrates that integration of multi-omics data can help identify critical molecular determinants for effective targeted therapeutics.
Institutions: Livestrong Foundation, The University of Texas at Austin, The University of Texas MD Anderson Cancer Center, Baylor Scott & White Medical Center - Temple, Baylor Scott & White Health, Harvard University, Dana-Farber Cancer Institute, Texas A&M Health Science Center, Texas A&M University, Oregon Health & Science University, OHSU Knight Cancer Institute, The University of Texas Southwestern Medical Center, Baylor College of Medicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Funders: U.S. Department of Defense, Breast Cancer Research Foundation, Breast Cancer Alliance, Cancer Prevention and Research Institute of Texas, Leukemia and Lymphoma Society, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, University of Texas at Austin, Susan G. Komen, Ovarian Cancer Research Alliance, Prospect Creek Foundation, National Institutes of Health, National Cancer Institute
Awards: Recruitment of First-Time, Tenure-Track Faculty Members, Determining the Immunological Consequences of DNA Replication Stress Response Defects in Renal Cells Carcinoma to Improve Immunotherapy Outcomes, G3698728727, G4711722764, G4746443639, Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer, Fostering Career Development: Functional Analyses of Molecular Interactome Perturbations by Cancer Mutations, Recruitment of First-Time, Tenure-Track Faculty Members, Recruitment of Established Investigators, G8227738726, G859303904, G8597306977
OpenAlex ID: W4361841697