Single file with supplemental methods, figures, tables, legends. from Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling
Year: 2023
Type: other
Abstract: SF1: TGF-β1 promotes Twist1-induced epithelial dissemination without loss of adherens junction protein expression; SF2: Prkd1 inhibitors kb-NB142-70 and Gö-6976 block Twist1- induced dissemination dose-dependently; SF3: Dissemination defects in Twist1-On organoids resulting from Prkd1 inactivation; SF4: Twist1-induced epithelial cells express Prkd1 and maintain β-catenin expression; SF5: Limited toxicity observed in response to drug treatment of Twist1-induced organoids; SF6: Supporting data for Figure 6: SF7: Molecular model for Twist1-induced epithelial dissemination; ST1: List of inhibitors tested in Figure 1; ST2: List of antibodies used in the study; ST3: Phosphoantibody microarray data. Supplementary movie legends.
Authors: Dan Georgess, Veena Padmanaban, Orit Katarina Sirka, Kester Coutinho, Alex Choi, Gabriela Frid, Neil M. Neumann, Takanari Inoue, Andrew J. Ewald
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361842111