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Supplementary Figure 1 from Oncogenic PI3K Mutations Lead to NF-κB–Dependent Cytokine Expression following Growth Factor Deprivation

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 450K, Quantification of data from Figure 1A. Figure S2: A subset of PI3K-driven genes is regulated by NF-�B. Figure S3: IKK inhibition decreases secretion of IL-6 and CXCL1. Figure S4: IKK inhibition does not decrease cell metabolic activity or susceptibility to apoptosis. Figure S5: Quantification of data from Figure 6. Figure S6: IL-6 receptor inhibition does not decrease proliferation of MCF10A cells expressing PIK3CA E545K.

DOI: 10.1158/0008-5472.22390539.v1

Authors: Jessica E. Hutti, Adam D. Pfefferle, Sean C. Russell, Mayukh Sircar, Charles M. Perou, Albert S. Baldwin

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361843722

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