Supplementary Figure 1 - 9 from Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 10382K, Time-of-flight mass spectrometry of phosphorylated Bcl-2 (S1); Thr69, Thr74 and Ser87 mutations increase affinity of Bcl-2 for Bak (S2); Ser70 mutations alter Bcl-2 conformation (S3); Effect of various Bcl-2 constructs on apoptosis induction by EGFP-BimEL and EGFP-Bak (S4); Bcl-2 Ser70 modifications increase MEF cell resistance to Bak-induced apoptosis (S5); Effect RNA interference for Bcl-2, Bcl-xL and Mcl-1 on induction of apoptosis by paclitaxel (S6); Effects of a second set of shRNAs targeting Bcl-2, Bcl-xL or Mcl-1 on paclitaxel-induced apoptosis (S7); Effect of navitoclax on paclitaxel-induced apoptosis in additional ovarian cancer cell lines (S8); Comparison of ability of ABT-199 and navitoclax to sensitize cells to paclitaxel (S9).
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361846532