Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 579K, Supplemantary Figure 1: Bcl-2 and Bcl-xL determine sensitivity to PI3K/AKT/mTOR inhibition. Supplementary Figure 2: AKT modulates sensitivity to ABT-737. Supplementary Figure 3: BEZ235/ABT-737 results in time-dependent induction of apoptosis. Supplementary Figure 4: PI3K inhibitors markedly increase Bim binding to Bcl-2 and Bcl-xL. Supplementary Figure 5: Overexpression of Bcl-2 or Bcl-xL protects leukemia cells against BEZ235/ABT-737 lethality Supplementary Figure 6: GSK3 inhibitors protect cells against BEZ235/ABT-737 lethality Supplementary Figure 7: In vivo anti-leukemic activity of BEZ235/ABT-737.
Authors: Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C. Williams, Andrea Ferreira-Gonzalez, Steven Grant
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361847342