Work

Supplementary Data 8 from Inhibition of EphB4–Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers

Year: 2023

Type: supplementary-materials

Abstract: Mice implanted with PDX tumors show significantly reduced uptake of supra-paramagnetic iron oxide nanoparticles (SPIO) in the combined sEphB4-HSA and RT group compared to the groups treated with RT alone or with sEphB4-HSA alone in DCE-MRI imaging (A-B). Delta T2 represents magnitude of decrease in T2 signal. One-way ANOVA was used to calculate the significance of the differences between groups. CIBERSORT analysis of a HNSCC TCGA dataset shows that patients with low M2:M1 ratio have improved overall survival (C) and disease-free survival (D). Analysis of HNSCC TCGA showing correlation between M2-related marker-HRH1 and ephrin-B2 (EFNB2) (E), EphB4 (F).

DOI: 10.1158/0008-5472.22418520.v1

Authors: Shilpa Bhatia, Ayman Oweida, Shelby Lennon, Laurel B. Darragh, Dallin Milner, Andy V. Phan, Adam C. Mueller, Benjamin Van Court, David Raben, Natalie J. Serkova, Xiao-Jing Wang, Antonio Jimeno, Eric T. Clambey, Elena B. Pasquale, Sana D. Karam

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361849110

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