Work

Supplementary Figures S1-S9 from Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair

Year: 2023

Type: supplementary-materials

Abstract: Figure S1. PNUTS depletion causes endogenous DNA damage. Figure S2. PNUTS depletion leads to DNA damage hypersensitivity. Figure S3. The recruitment of PNUTS to DNA damage sites is dependent on PARP1. Figure S4. PNUTS is required for the efficient induction of PARylation after DNA damage. Figure S5. PNUTS binds the middle segment of PARP1, and promotes its recruitment to laser-induced DNA damage sites. Figure S6. PNUTS knockdown impairs the recruitment of GFP-PARP1 to laser-induced DNA damage sites. Figure S7. PNUTS knockdown disrupts the recruitment of PARP1 to laser-induced DNA damage sites. Figure S8. PNUTS targeting sensitizes SCC38 cells to PARP inhibition. Figure S9. PNUTS targeting sensitizes HeLa cells to PARP inhibition.

DOI: 10.1158/0008-5472.22418430

Authors: Feifei Wang, Songli Zhu, Laura A. Fisher, Ling Wang, Nicholas J. Eurek, James K. Wahl, Li Lan, Aimin Peng

Institutions: Anhui University, University of Nebraska Medical Center, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

OpenAlex ID: W4361849390

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