Work

Supplementary Figure S5 from FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S5 demonstrates that silvestrol treatment does not affect mouse body weight and proliferation rate of tumor cells, but selectively inhibits translation of WNT signaling components, and also shows that EIFA1 levels predominate EIF4A2 expression in the WNT/iR1 model, whose tumors are enriched with basal-like and Her2 signatures.

DOI: 10.1158/0008-5472.22418622.v1

Authors: Tuan M. Nguyen, Elena B. Kabotyanski, Yongchao Dou, Lucas C. Reineke, Peng Zhang, Xiang H.-F. Zhang, Anna Malovannaya, Sung Yun Jung, Qianxing Mo, Kevin P. Roarty, Yiwen Chen, Bing Zhang, Joel R. Neilson, Richard E. Lloyd, Charles M. Perou, Matthew J. Ellis, Jeffrey M. Rosen

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361849408

Cites:

Cited by:

Related to: 10