Supplemental figures from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 1: Chemical structures of mitochondria-targeted metformin analogs and the synthetic pathway. Supplemental Figure 2: Effects of Met and Mito-Met10 on proliferation of mouse pancreatic cancer cells. Supplemental Figure 3: The effects of Mito-Met10, Met and other mitochondria-targeted agents (MTAs) on intracellular ATP level and cell death in MiaPaCa-2 cells. Supplemental Figure 4: Mito-Met10, but not control long chain compound (Dec-TPP+), exhibits selectivity in inhibition of cancer cell viability. Supplemental Figure 5: Effects of Mito-Met2 and Mito-Met6 on PDAC proliferation. Supplemental Figure 6: Intracellular concentrations of Mito-Met10 in cancer and normal cells. Supplemental Figure 7: Intracellular redox signaling in Mito-Met10-treated PDAC cells. Supplemental Figure 8: Measurement of respiratory activity in permeabilized cells using extracellular flux analysis and effects of Mito-Met10 and Met on mitochondrial complex I activity. Supplemental Figure 9: Mito-Met10 and metformin directly inhibit pyruvate-driven, but not succinate-driven, respiration in permeabilized cells. Supplemental Figure 10: High concentrations of Mito-Met10 induce cellular oxidants in HPNE cells. Supplemental Figure 11: Tissue accumulation of Mito-Met10 in in vivo FC-1242-luc orthotopic mouse model.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361850201