Methods and Supplementary Figures 1-9 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Year: 2023
Type: supplementary-materials
Abstract: Methods and Supplementary Figures 1-9. Supplementary Figure 1: Histopathology images of tumors used in ischemia time-course and spatial heterogeneity experiments. Supplementary Figure 2: Schematic overview of ovarian tumor ischemia time-course experiment. Supplementary Figure 3: Distinct inter-patient ischemia regulated temporal dynamics are observed. Supplementary Figure 4: Similar ischemia response temporal patterns are observed across ovarian tumors. Supplementary Figure 5: Schematic overview of the colon tumor spatial heterogeneity and ischemia time-course experiment. Supplementary Figure 6: Spatial phosphorylation heterogeneity in colons tumors cannot be attributed solely to technical measurement error. Supplementary Figure 7: Weak correlations and minimal shared covariance between spatially proximal colon tumor samples. Supplementary Figure 8: Schematic overview of the colon tumor protein expression profiling experiment. Supplementary Figure 9: Delayed freezing of tumors affects pTyr sites involved in numerous pathways and processes.
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4361850522