Work

Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport

Year: 2023

Type: supplementary-materials

Abstract: (A) Cytosolic extraction of brat-RNAi (bratIR) Drosophila brains shows higher levels of NICD compared to the control brain. (B) Nuclear extract also shows higher NICD in brat-RNAi compared to control suggesting increased NICD nuclear transport. (C) Densitometric quantification of nuclear NICD.

DOI: 10.1158/0008-5472.22410861.v1

Authors: Subhas Mukherjee, Carol Tucker-Burden, Changming Zhang, Kenneth Moberg, Renee Read, Costas Hadjipanayis, Daniel J. Brat

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361850863

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