Legends of Supplemental Figure 1-11 from CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion
Year: 2023
Type: other
Abstract: The figure legends of Supplemental figure 1-11 which include: (1) High resolution image of figure 1A. (2) Supplemental data for the relation between CCR5+ cells and breast cancer stem cells. (3) In vivo tumor formation of CCR5+ vs CCR5- cells. (4) In vivo tumor formation of CCR5 overexpression cells vs vector control cells. (5) Gene expression profile of CCR5+ vs CCR5- cells. (6) The effects of CCR5 on DNA damage repair in MDA-MB-231 cells. (7) A schematic representation of the DNA damage signaling pathways, with target genes enriched in CCR5+ cells. (8) The effects of CCR5 on DNA damage repair based on DNA damage repair reporter assays. (9) The functional synergy of cell killing between CCR5 inhibitors and Doxorubicin. (10) Single cell RNAseq of CCR5+ vs. CCR5- SUM-159 cells. (11) Enrichment of CCR5+ cells in doxorubicin resistant cells.
Authors: Xuanmao Jiao, Marco A. Velasco-Velázquez, Min Wang, Zhiping Li, Hallgeir Rui, Amy R. Peck, James E. Korkola, Xuelian Chen, Shaohua Xu, James B. DuHadaway, Sandra Guerrero-Rodriguez, Sankar Addya, Daniela Sicoli, Zhaomei Mu, Gang Zhang, Andres Stucky, Xi Zhang, Massimo Cristofanilli, Alessandro Fatatis, Joe W. Gray, Jiang F. Zhong, George C. Prendergast, Richard G. Pestell
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361850786