Supplementary Figures 1-13 from Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 1MB, Supplemental Figures 1-13 - Figure S1. Average levels of focal amplification and deletion along the chromosome arm; Figure S2. Patterns of chromosomal instability differ across adenocarcinomas of the gastrointestinal tract after removing samples without arm-level alterations; Figure S3. Numbers of high-level amplifications and deletions using arm-level based thresholds; Figure S4. Identification of arm-level alterations in esophageal, gastric, and colorectal adenocarcinomas; Figure S5. Comparison of SNP6.0 and 250K adenocarcinoma data to Progenetix database; Figure S6. Significance of focal amplifications in esophageal, gastric, and colorectal adenocarcinomas; Figure S7. Variable levels of focal alterations across gut adenocarcinomas; Figure S8. KRAS alterations differ across gut adenocarcinomas; Figure S9. Quantitative real-time PCR confirms FGFR2 amplification in EA tumors; Figure S10. Focal alterations in gut adenocarcinomas shared with all cancers; Figure S11. Significance of focal deletions in esophageal, gastric, and colorectal adenocarcinomas; Figure S12. Length distribution of SCNAs in gut adenocarcinomas; Figure S13. Observed distribution of copy number event amplitudes in the data set.
Authors: Austin M. Dulak, Steven E. Schumacher, Jasper van Lieshout, Yu Imamura, Cameron Fox, Byoungyong Shim, Alex H. Ramos, Gordon Saksena, Sylvan C. Baca, Jose Baselga, Josep Tabernero, Jordi Barretina, Peter C. Enzinger, Giovanni Corso, Franco Roviello, Lin Lin, Santhoshi Bandla, James D. Luketich, Arjun Pennathur, Matthew Meyerson, Shuji Ogino, Ramesh A. Shivdasani, David G. Beer, Tony E. Godfrey, Rameen Beroukhim, Adam J. Bass
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361872179