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Supplementary Figure 2 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure 2 - PDF file 25K, Schema demonstrating how miR-124 exerts target effects on the STAT3 pathway in gCSC cells. STAT3 can be activated by a variety of ligands such as IL-6 or EGFR. miR-124 can not only down-modulate SHC1, STAT3, P-STAT3 in all tested gCSC cell lines but also, occasionally, pMAPK1/3, probably in a contextual fashion when the IL-6R ligand is not present and the gCSC is dependent on EGFR signaling

DOI: 10.1158/0008-5472.22394880

Authors: Jun Wei, Fei Wang, Ling-Yuan Kong, Shuo Xu, Tiffany Doucette, Sherise D. Ferguson, Yuhui Yang, Kayla McEnery, Krishan Jethwa, Olsi Gjyshi, Wei Qiao, Nicholas B. Levine, Frederick F. Lang, Ganesh Rao, Gregory N. Fuller, George A. Calin, Amy B. Heimberger

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361872653

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