Supplementary Table S9 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Year: 2023
Type: supplementary-materials
Abstract: Simulation of tumor mutational heterogeneity. Estimates are for the minimum number of cell replications required for two randomly chosen cells to possess the number of mutational differences observed in paired cell lines at a greater than 99% probability. Data were simulated using fixed mutation probabilities of 10-8 per base per cell replication for non-hypermutated and 10-6 for hypermutated MSI-H tumors.
Authors: Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony W. Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L. Wilding, David Bicknell, Ian P.M. Tomlinson, Walter F. Bodmer, John M. Mariadason, Oliver M. Sieber
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361873962