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Supplementary Figures S1-S6 from PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figures S1-S6. BrafV600E::Cdkn2a-/- delay development of tumors in PtenWT::Pdk-/-genotype (S1); Inhibition of SGK1 or SGK3 resembles changes in signaling seen upon PDK1 inhibition (S2); SGK and PDK1 inhibition affect cell cycle progression (S3); Synthetic lethal screen for PDK1i combination drugs (S4); RPPA analysis of signaling components that are affected upon inhibition of PDK1 (S5); PDK1 KD reduces the expression of genes involved in pigmentation and metastasis (S6).

DOI: 10.1158/0008-5472.22408047

Authors: Marzia Scortegagna, Eric Lau, Tongwu Zhang, Yongmei Feng, Chris Sereduk, Hongwei Yin, Surya K. De, Katrina Meeth, James T. Platt, Casey G. Langdon, Ruth Halaban, Maurizio Pellecchia, Michael A. Davies, Kevin Brown, David F. Stern, Marcus Bosenberg, Ze'ev A. Ronai

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361874757

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