Supplementary Figures S1-S12 from Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells
Year: 2023
Type: supplementary-materials
Abstract: siRNA mediated knock-down of VEGF in CRC cells (S1); Proliferation of CRC cells is not effected by blocking paracrine/Autocrine VEGF signaling (S2); VEGF depletion in CRC cells affect survival signaling (S3); Validation of VEGFR1 inhibitors (S4); Depletion but not inhibition of VEGFR1 in CRC cells lead to reduced survival signaling (S5); CRC cells have insignificant amounts of secreted VEGFR1 (S6); VEGF and VEGFR1 interact in CRC cells (S7); Localization of VEGF and VEGFR1 in CRC cells (S8); Possible mechanisms of VEGF depletion and it's effects on phosphorylation status of AKT in CRC cells (S9). VEGF depletion effects phosphorylation of multiple RTKs in CRC cells (S10); Overexpression of RTKs can rescue pAKT levels in VEGF depleted CRC cells (S11); Potential mechanism of intracrine VEGF signaling in CRC cells (S12).
Authors: Rajat Bhattacharya, Xiang-Cang Ye, Rui Wang, Xia Ling, Madonna McManus, Fan Fan, Delphine Boulbes, Lee M. Ellis
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361874793