Supplementary Materials and Methods, Supplementary Figures 1 through 5, and Supplementary Tables 1 through 3 from Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Materials and Methods describing 16S rRNA sequencing analysis. Figure S1. PCR detection of F. nucleatum adhesins. Figure S2. ApcMin/+;Il10-/- mice have increased colon proliferation. Figure S3. Bacteria do not promote colon inflammation and tumorigenesis in ApcMin/+ mice. Figure S4. Microbiota promote proximal colon proliferation in ApcMin/+;Il10-/- mice. Figure S5. Colibactin promotes CRC development in AOM/Il10-/- mice. Table S1. Spearman correlations and corresponding p values from linear models used to generate Figure 3. Table S2. V1-V3 MiSeq Primers. Table S3. Accession numbers for 16S rRNA sequenced ApcMin/+;Il10-/- stool samples from Figure 3.
Institutions: University of North Carolina at Chapel Hill, University of North Carolina at Charlotte, University of Florida, Université Toulouse III - Paul Sabatier, Inserm, École Nationale Vétérinaire de Toulouse, Centre Hospitalier Universitaire de Toulouse, Institut de Recherche en Santé Digestive, Université de Toulouse
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361875412