Supplementary Figures S1-S13 from Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
Year: 2023
Type: supplementary-materials
Abstract: STING co-immunoprecipitates with IRE-1 (S1); Chemical structures of STING agonists (S2); Analysis of 3'3'-cGAMP by RP-HPLC and NMR (S3); STING does not undergo N-linked glycosylation before and after stimulations by 3'3'-cGAMP (S4); Deletion of mouse STING gene by ZFN (S5); STING-null A20 cells are resistant to 3'3'-cGAMP-induced apoptosis (S6); Tandem MS spectra of phosphorylated S357 and S365 peptides of mouse STING (S7); The affinity-purified anti-STING antibody specifically immunostains mouse STING in 5TGM1 myeloma cells (S8); An IRE-1/XBP-1 pathway inhibitor, B-I09, enhances the cytotoxicity of 3'3'-cGAMP in normal and malignant B cells (S9); STING agonists do not induce apoptosis, but elicit phosphorylation of IRF3 and STAT1 in melanoma, hepatoma, and Lewis lung cancer cells (S10); STING agonists do not induce apoptosis in normal T cells (S11); STING-deficient 5TGM1 and A20 cells respond normally to ER stress inducers, and exhibit normal intracellular transport of class I MHC molecules (S12); 5TGM1 myeloma cells grafted subcutaneously in immunodeficient NSG mice do not migrate to bone marrow, peripheral blood and spleens (S13).
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361875428