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Supplementary Figure 2 from Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline CDH1 Variants

Year: 2023

Type: supplementary-materials

Abstract: a. The Cancer Genome Atlas algorithm to categorize gastric cancer into four molecular subtypes: Epstein-Barr virus infected (EBV, red), microsatellite instability (MSI, blue), chromosomal instability (CIN, purple), and genomically stable (GS, green). SCNA = somatic copy number alterations. b. MSIsensor score. Whole-exome sequence data from each Hispanic/Latino cancer sample were analyzed with MSIsenor. Gray bar denotes total mutation burden per megabase. Yellow bar denotes calculated MSIsensor score. Samples with score {greater than or equal to} 10 were considered to be microsatellite unstable.

DOI: 10.1158/0008-5472.22424391

Authors: Sam C. Wang, Yunku Yeu, Suntrea T.G. Hammer, Shu Xiao, Min Zhu, Changjin Hong, Jean R. Clemenceau, Lynn Y. Yoon, Ibrahim Nassour, Jeanne Shen, Deepak Agarwal, Scott I. Reznik, John C. Mansour, Adam C. Yopp, Hao Zhu, Tae Hyun Hwang, Matthew R. Porembka

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361877361

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