Supplementary Data from Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 1: Subtype LC2 specific MEN1 loss of heterozygosity. Supplementary Figure 2: PCA on gene expression for top variable number of genes. Supplementary Figure 3: Pearson correlation on top 3000 variable genes. Supplementary Figure 4: Heatmap of top 100 variable genes. Supplementary Figure 5: PCA of top variable number of CpG sites. Supplementary Figure 6: Boxplot of gene expression of HNF1A, FOXA3 and HNF4A across three LC subtypes. Supplementary Figure 7: Low expression of HOX family members in LC2 subtype. Supplementary Figure 8: Heatmap of LCs classifier from 30 LC dataset on independent lung carcinoids cohort from Fernandez-Cuesta et al. Supplementary Figure 9: Heatmap of HNF1A, FOX3 and FEV on Fernandez-Cuesta et al gene expression dataset. Supplementary Figure 10: Key targets of ASCL1 transcription factor. Supplementary Figure 11: Clinical features of three LC subtypes for median age of diagnosis. Supplementary Table1: Tumor purity scores for 30 LC samples using gene expression profile. Supplementary Table2: Significant Pathways/Gene Ontologies for top 100 variable genes. Supplementary Table3: Global methylation CpG count under hypo (beta <0.3) and hyper (beta >=0.7) methylated probes for 18 LC samples. Supplementary Table4: IHC staining results for ASCL1 and S100 biomarker in 20 LC dataset
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361877499