Figure S4 from Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
Year: 2023
Type: other
Abstract: Somatic mutations and homozygous deletions targeting chromatin regulators in ASCP genomes. IGV views of A) TP53Y205S and MSL2C44W in 3.8N population sorted from primary tumor 9R. B) KRASG12D and KANSL1Q396X in flow sorted tumor fraction in PAX217. Sorted 2.0N fraction was used as a patient matched normal for 9R while patient matched lymphocytes were used as a source of normal DNA for PAX217. Homozygous deletions (log2 ratio <-3.0) targeting ASXL2 and ARID2 in C) PENN040 and D) PAX208.
Authors: Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham, William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M. Grandgenett, Michael A. Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C. Hernandez, Jennifer L. Leiting, Ronald M. Evans, Tamas Ordog, Mark J. Truty, Mitesh J. Borad, Tannishtha Reya, Daniel D. Von Hoff, Martin E. Fernandez-Zapico, Michael T. Barrett
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361878065