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Supplementary Figure 5 from Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 140K, HT29 and Colo205 parental and PLX-resistant (RC) cell lines were profiled by Affymetrix MIP array (OncoScan� FFPE Express 2.0 Services) for copy number. The following copy number plots were produced by Affymetrix Nexus CN 6.0. (build 6461). In the HT29 parental and HT29RC, the black arrows represent an increase in copy number in chromosome 7p acquired in the HT29RC. Similarly, in the Colo205RC, there is an acquired increase in copy number in chromosome 12p, denoted by the black arrow.

DOI: 10.1158/1078-0432.22445835

Authors: Muling Mao, Feng Tian, John M. Mariadason, Chun C. Tsao, Robert Lemos, Farshid Dayyani, Y.N. Vashisht Gopal, Zhi-Qin Jiang, Ignacio I. Wistuba, Xi M. Tang, William G. Bornman, Gideon Bollag, Gordon B. Mills, Garth Powis, Jayesh Desai, Gary E. Gallick, Michael A. Davies, Scott Kopetz

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361881812

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