Supplementary Figure 5 from T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 94K, Expansion and antitumor activity of T cells expressing a second versus a third generation CAR.CSPG4. Panel A illustrates the expansion of control, CAR.CSPG4 (2nd gen, CD28 costimulation), and CAR.CSPG4 (3rd gen, CD28/4-1BB costimulation) within 14 days of culture. Data represents the average of 4 T-cell lines with mean � SD. Panel B. Summary of co-culture experiments of anti-tumor activity of control, CAR.CSPG4+ T cells either 2nd or 3rd generation against a panel of CSPG4+ tumor targets. Data represent averages of 3 donors with mean � SD. * = p<0.05, and *** = p<0.001.
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361882722