Supplementary Figure 1 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 69KB, MLN4924-induces apoptosis of the CLL B-cells on CD40L-expressing stroma is independent of IGHV mutational status (A) and cytogenetics (B, C). CLL cells were cultured on CD40L-expressing stroma for 24 hours, followed by incubation with 1 μM MLN4924 or vehicle control for 48 hours. Apoptosis within CD19+ subset of cells was determined by Annexin V and 7-AAD staining and normalized to the time-matched untreated controls. Horizontal lines represent the mean. (C) % apoptosis plotted against the size of a 17p deletion clone in 11 individual CLL samples (r=-0.2, p=0.56).
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361883033