Supplementary Figure 3 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 107KB, MLN4924-induced apoptosis is accompanied by loss of canonical NFkappaB activation. CLL cells were co-cultured with CD40L-expressing stroma for 24 hours in the presence or absence of 10 ng/ml IL4. Thereafter, cell were incubated with 1 microM MLN4924 for 24 hours and immunostained with p65 and cleaved PARP antibodies. Nuclei were counterstained with 4,6-diamino-2-phenylindole. A representative case (out of 3) is shown.
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361883111