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Supplementary Figure 4 from Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 108KB, Distribution of the mutations along the Top1mt polypeptide. Red: Deleterious missense variants. Blue: Essential amino acids (aa) for Top1mt activity. Green: High frequent missense variants.

DOI: 10.1158/1078-0432.22455437

Authors: Salim Khiati, Ilaria Dalla Rosa, Carole Sourbier, Xuefei Ma, V. Ashutosh Rao, Leonard M. Neckers, Hongliang Zhang, Yves Pommier

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361884078

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