Supplementary Figures from Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig. 1. IB inhibits the growth of breast cancer cells in a dose and time dependent manner. Supplementary Fig. 2. IB inhibits migration and invasion of breast cancer cells. Supplementary Fig. 3. IB treatment inhibits in vivo growth and metastasis of breast tumorigenesis. Supplementary Fig. 4. IB is safe and effective against human breast cancers. Supplementary Fig. 5. (A) Western blot analysis of MCF-7 cells treated with vehicle or IB (5μM) using antibodies against FOXM1, SKP2, PLK1 and XRCC3. Supplementary Fig. 6. (A) Western blot analysis of MCF-7 cells treated with vehicle or IB (5μM) using antibodies against cyclin D 1, CDK4, cyclin E2, CDK2. Supplementary Fig. 7. (A) A549, HeLa and DU145 cells were treated with various doses of IB (1-5 μM) for 24 hours and then cells were re-seeded in 6-well plate and allowed to grow for additional 7 days before colonies were stained with crystal violet.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361884466