Work

Figure S1 from The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

Year: 2023

Type: other

Abstract: Candidate MCT4-targeting ASOs are able to inhibit cell proliferation and MCT4 expression of LNCaP human prostate cancer cells 48 hours after transfection. A) MCT4 ASOs are able to inhibit LNCaP cell proliferation to levels comparable to those observed with other human prostate cancer cell lines. B) The decrease in cell proliferation is associated with a decrease in MCT4 expression. Taken together, the data suggest that the inhibitory effect of MCT4 ASOs may be more associated with a glycolytic phenotype than with androgen receptor status.

DOI: 10.1158/1078-0432.22457358

Authors: Stephen Yiu Chuen Choi, Hui Xue, Rebecca Wu, Ladan Fazli, Dong Lin, Colin C. Collins, Martin E. Gleave, Peter W. Gout, Yuzhuo Wang

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361884553

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