Supplementary Information, tracked changes accepted from Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Table 1: Laboratory values (Liver Function Tests) Supplementary Table 2: Overview of mean pCT parameters for tumour VOI on sequential scans Supplementary Table 3: Overview of median DCE-MRI parameters, Ktrans, Ve and Kep for tumour VOI on sequential scans. Mean across all patients of the median per patient values is shown. Supplementary Table 4: Correlations of baseline characteristics, mutation status & overall mrTRG score with TCD. Supplementary Table 5 Correlations of baseline characteristics, mutation status & overall mrTRG score with median Ktrans. Supplementary Table 6: Correlations of baseline characteristics, mutation status & overall mrTRG score with mean Blood Flow. Supplementary Figure 1: Axial and sagittal images from T2W MRI scans at baseline and 8 weeks after completion of therapy. Supplementary Figure 2: Perfusion parameter maps illustrating an increase in Blood Flow and reduction in MTT between Scans 2 and 3. Supplementary Figure 3: Examples of (a) positive immunohistochemistry staining in pre-treatment rectal tumour biopsies and (b) absent staining in negative control.
Authors: Esme J. Hill, Corran Roberts, Jamie M. Franklin, Monica Enescu, Nicholas West, Thomas P. MacGregor, Kwun-Ye Chu, Lucy Boyle, Claire Blesing, Lai-Mun Wang, Somnath Mukherjee, Ewan M. Anderson, Gina Brown, Susan Dutton, Sharon B. Love, Julia A. Schnabel, Phil Quirke, Ruth Muschel, William G. McKenna, Michael Partridge, Ricky A. Sharma
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361884703