Figure S2 from HMGA2–FOXL2 Axis Regulates Metastases and Epithelial-to-Mesenchymal Transition of Chemoresistant Gastric Cancer
Year: 2023
Type: other
Abstract: RT-PCR analysis of HMGA2-FOXL2 pathway associated molecules. A. The mRNA expression levels of E-cadherin, Vimentin, Snail1 and ZEB2 were analysed when FOXL2 was suppressed. **P<0.01. B. The alterations to E-cadherin, Vimentin and Snail1 was analysed after HMGA2 was knocked down. **P<0.01. C. The alterations to E-cadherin, Vimentin, Snail1 and ZEB2 caused by ectopic FOXL2. **P<0.01. D. The effects of ectopic HMGA2 on E-cadherin, Vimentin and Snail1. **P<0.01. E. CDC2, CCNE1 and TK1 were increased by ectopic E2F1 and HMGA2. **P<0.01. F. Knockdown of E2F1 suppressed CDC2, CCNE1 and TK1. **P<0.01. G. CDC2, CCNE1 and TK1 were increased by inhibiting Rb. **P<0.01.
Authors: Jiaqiang Dong, Rui Wang, Gui Ren, Xiaowei Li, Jingbo Wang, Yi Sun, Jie Liang, Yongzhan Nie, Kaichun Wu, Bin Feng, Yulong Shang, Daiming Fan
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361885559