Supplementary Figures from Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig. S1. Romidepsin derepresses SLFN11 expression in cancer cell lines from the NCI-60. Supplementary Fig. S2. Forcing SLFN11 expression sensitizes human colon cancer HCT116 cells to camptothecin. Supplementary Fig. S3. Induction of SLFN11 independently of FLI1, rapid reversal of the romidepsin effect and short half-life of SLN11 transcripts. Supplementary Fig. 4. Derepression of SLFN11 by entinostat sensitizes H82 and HH cells to camptothecin and exhibit additive effect in H446 cells.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361886137