Figure S4 from PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition
Year: 2023
Type: other
Abstract: Figure S4. Association between sensitivity to PI3K/mTOR pathway inhibitors and human papilloma virus (HPV) status and proteomic scores in head and neck squamous cell carcinoma (HNSCC) cell lines. A and B. The sensitivity of HPV-positive cells to each drug using area under curve (AUC) values (A) or 70% inhibitory concentration (IC70) values (B) was compared with that of HPV-negative cells; no significant differences were found. P values were calculated using a two-sample t-test. C-D. Spearman correlation analysis was used to assess associations between IC70 values and epithelial to mesenchymal (EMT) and DNA repair proteomic scores with the indicated p values. The dashed blue lines indicate trend line, the red lines indicate local regression line (LOWESS line) and the shaded area represent 95% confidence interval.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361887131