Supplementary Data from Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer
Year: 2023
Type: supplementary-materials
Abstract: Figure S1. Gene order within the cluster defined groups. Figure S2. Analysis of individual hypoxia and immune gene signatures. Figure S3. Flow diagram showing progress of patient samples through study for Correlate cohort Figure S4. Relationship between heatmap defined hypoxia-immune subgroups and T stage. Figure S5 Expression of individual hypoxia- or immune-response related genes within the heat-map defined subgroups. Figure S6. Correlation of PD-L1 or CA-IX protein expression with survival. Figure S7 Correlation of gene and protein expression. Figure S8. Spatial interactions of hypoxia and immune cells: Vectra images of multiplex stained HNC sections. Table S1 Treatment schedules Table S2. Genes in the RNASeq panel/TCGA dataset Table S3. Relationship of hypoxia-immune classifier to other prognostic variables Table S4. Summary of immunohistochemistry staining Table S5. Summary of statistical analyses for IHC staining
Authors: Jill M. Brooks, Albert N. Menezes, Maha Ibrahim, Lucinda Archer, Neeraj Lal, Christopher J. Bagnall, Sandra V. von Zeidler, Helen R. Valentine, Rachel J. Spruce, Nikolaos Batis, Jennifer L. Bryant, Margaret Hartley, Baksho Kaul, Gordon B. Ryan, Riyue Bao, Arun Khattri, Steven P. Lee, Kalu U.E. Ogbureke, Gary Middleton, Daniel A. Tennant, Andrew D. Beggs, Jonathan Deeks, Catharine M. L. West, Jean-Baptiste Cazier, Benjamin E. Willcox, Tanguy Y. Seiwert, Hisham Mehanna
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361887251