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Supplementary Figure 7A, B from Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

Year: 2023

Type: supplementary-materials

Abstract: Re-expression of RIPK3 expression triggers necroptosis in RIPK3-negative MM cell lines, and RIPK3 inhibition rescues the cell death caused by necroptosis. A, RIPK3-negative MM cell lines M12 and M22 were transduced with WPI lentivirus expressing RIPK3 WT or empty vector and treated with the apoptosis inhibitor zVAD and/or the RIPK3 inhibitor GSK'872 for 1-4 d. Results of immunoblot analysis (24 h) and clonogenic assay (4 d) are shown. B, Cell viability determined with hemocytometer and trypan blue dye exclusion test.

DOI: 10.1158/1078-0432.22473987

Authors: Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran, Joseph R. Testa

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361888146

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