Figure S2 from Functional Properties of KIT Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia
Year: 2023
Type: other
Abstract: Supplemental Figure 2. Functional Evaluation and TKI response of E11 mutations. (A) Evaluation of the phosphorylation status of KIT following transfection of the mutations in exon 11, V559D and L576P, into HEK293 cell line. (B) IL-3 independent growth following transduction into Ba/F3 cells. (C) pKIT response following dasatinib exposure in HEK293 cell line transfected with E11 V559D mutation. (D) pKIT response following crenolanib exposure in HEK293 cell line transfected with E11 V559D mutation. (E) pKIT response following dasatinib exposure in HEK293 cell line transfected with E11 L576P mutation. (F) pKIT response following crenolanib exposure in HEK293 cell line transfected with E11 V559D mutation.
Authors: Katherine Tarlock, Todd A. Alonzo, Yi-Cheng Wang, Robert B. Gerbing, Rhonda Ries, Michael R. Loken, Laura Pardo, Tiffany Hylkema, Jason Joaquin, Leela Sarukkai, Susana C. Raimondi, Betsy Hirsch, Lillian Sung, Richard Aplenc, Irwin Bernstein, Alan S. Gamis, Soheil Meshinchi, Jessica A. Pollard
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361888173