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Figure from Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

Year: 2023

Type: supplementary-materials

Abstract: Restoration of RIPK3 expression triggers necroptosis in RIPK3-negative MM cells. A, Lentivirus expressing RIPK3-WT, RIPK3-KD, or empty vector only was used to transduce RIPK3-negative MM cells at MOI=5. Flow cytometry analysis of MM cells stained with AnnexinV and PI. B, Bar graphs depicting percentages of early apoptotic (AnnexinV only), later apoptotic (AnnexinV+PI), and necrotic (PI only) populations.

DOI: 10.1158/1078-0432.22474014

Authors: Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran, Joseph R. Testa

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361888402

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