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Supplementary Figure S2 from Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin

Year: 2023

Type: supplementary-materials

Abstract: Gene expression analysis of NECTIN4 correlates. (A) Correlation between NECTIN4 and GATA3 mRNA expression across the Seiler 2017 (left), Sjödahl 2012 (middle), and TCGA (right) cohorts. (B) Correlation between NECTIN4 and FOXA1 mRNA expression across Seiler 2017 (left), Sjödahl 2012 (middle), and TCGA (right) cohorts. (C) Correlation between NECTIN4 and PPARG mRNA expression across Seiler 2017 (left), Sjödahl 2012 (middle), and TCGA (right) cohorts. (D) Centroid values from the consensus molecular classifier by Kamoun et al. for NECTIN4, FOXA1, GATA3, and PPARG. (E) Kaplan-Meier curves of overall survival stratified by quartiles of NECTIN4 mRNA expression in TCGA (p=0.11), Sjödahl 2012 (p=0.6), and Seiler 2017 (p=0.06) cohorts.

DOI: 10.1158/1078-0432.22481589

Authors: Carissa E. Chu, Martin Sjöström, Emily A. Egusa, Ewan A. Gibb, Michelle L. Badura, Jun Zhu, Vadim S. Koshkin, Bradley A. Stohr, Maxwell V. Meng, Raj S. Pruthi, Terence W. Friedlander, Yair Lotan, Peter C. Black, Sima P. Porten, Felix Y. Feng, Jonathan Chou

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361890067

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