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Supplementary Figure S7 from Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin

Year: 2023

Type: supplementary-materials

Abstract: (A) NECTIN4 surface protein expression in UMUC-14, 647V and HT-1376 cells. Gray denotes unstained control cells and red denotes NECTIN4-PE antibody stain. (B) Combined histograms of NECTIN4 surface protein expression in UMUC-14 (purple), 647V (green) and HT-1376 (blue) cells. (C) Western blot of NECTIN4 protein expression in whole cell lysates of UMUC-14, 647V and HT-1376 cells. (D) Phase-contrast brightfield microscopy of UMUC-14 and 647V bladder cancer cells. Scale bar = 200 mm. (E) EV dose-response assay in UMUC-14 (purple, basal), 647V (green, basal) and HT-1376 (blue, luminal) cells.

DOI: 10.1158/1078-0432.22481574

Authors: Carissa E. Chu, Martin Sjöström, Emily A. Egusa, Ewan A. Gibb, Michelle L. Badura, Jun Zhu, Vadim S. Koshkin, Bradley A. Stohr, Maxwell V. Meng, Raj S. Pruthi, Terence W. Friedlander, Yair Lotan, Peter C. Black, Sima P. Porten, Felix Y. Feng, Jonathan Chou

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361890300

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