Work

Supplementary Figures and Table from Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

Year: 2023

Type: supplementary-materials

Abstract: Fig S1: Site density cell lines with cytokine analyses of normal healthy donors and patient-derived CD22 CART. Fig S2: Development and evaluation of high-affinity CD22V1 CAR. Fig S3: PKCB2 effects of Bryostatin1 and CD22 modulation with PKC-inhibitors. Fig S4: RNA-seq analysis of Bryostatin1 effects on KOPN8 and SEM Fig S5: Exhaustion markers in Bryostatin1 and CD19 CAR with Bryostatin1 Fig S6: Bioluminescence for Bryostatin1 in vivo experiments Table S1: Enrichment analysis of RNA-seq Bryostatin1-treated cells specific to intrinsic components of the plasma membrane

DOI: 10.1158/1078-0432.22470984

Authors: Sneha Ramakrishna, Steven L. Highfill, Zachary Walsh, Sang M. Nguyen, Haiyan Lei, Jack F. Shern, Haiying Qin, Ira L. Kraft, Maryalice Stetler-Stevenson, Constance M. Yuan, Jennifer D. Hwang, Yang Feng, Zhongyu Zhu, Dimiter Dimitrov, Nirali N. Shah, Terry J. Fry

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361890846

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