Supplementary Figures 1-6 from Loss of SNAIL Regulated miR-128-2 on Chromosome 3p22.3 Targets Multiple Stem Cell Factors to Promote Transformation of Mammary Epithelial Cells
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 1291K, FIGURE S1: Representative data of genomic real-time PCR screening for DNA copy numbers of aberrant microRNAs on human chromosome 3p in breast carcinoma and the correlation between expression levels of miR-128 and ARPP21; FIGURE S2: miR-128 depletion confers non-tumorigenic MCF-10A cells with a malignant phenotype in vitro; FIGURE S3: Forced expression of miR-128 alters the morphology and reduces migration and invasion of MCF-7 cells in vitro, whereas miR-128 depletion confers non-tumorigenic HBL-100 cells with a malignant phenotype in vitro; FIGURE S4: miR-128 depletion confers a malignant phenotype on non-tumorigenic MCF-10A cells in vivo and miR-128 represses the CD44+CD24 Neg/Low population in mammary carcinoma cells; FIGURE S5: Interactions between miR-128 and its binding targets; FIGURE S6: Luciferase assay for promoter activity
Authors: PengXu Qian, Arindam Banerjee, Zheng-Sheng Wu, Xiao Zhang, Hong Wang, Vijay Pandey, Wei-Jie Zhang, Xue-Fei Lv, Sheng Tan, Peter E. Lobie, Tao Zhu
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361809519