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Supplementary Figure 7 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 1105K, Supplemental Figure 7. KISS1 inhibits glucose uptake and activation of AMPK. A, Glucose uptake by C8161.9Vector (Vec), C8161.9KFMΔSS, C8161.9KFM and C8161.9KFM/shPGC1α cells was measured using 2-deoxyglucose uptake and normalized to total protein. B, C8161.9Vector, C8161.9KFM and C8161.9KFMdeltaSS cells were treated with AICAR followed by Western blot with antibodies for AMPK, phospho-AMPK (Thr172), mTOR , phospho-mTOR (Ser2448), KISS1 and GAPDH.

DOI: 10.1158/0008-5472.22400877.v1

Authors: Wen Liu, Benjamin H. Beck, Kedar S. Vaidya, Kevin T. Nash, Kyle P. Feeley, Scott W. Ballinger, Keke M. Pounds, Warren L. Denning, Anne R. Diers, Aimee Landar, Animesh Dhar, Tomoo Iwakuma, Danny R. Welch

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361895849

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