Supplemental Table S3 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Table S3. Summary of siRNA follow-up studies. siRNAs were evaluated in the context of a camptothecin dose response. The primary screen rank is listed for each gene along with the number of siRNAs yielding a 2-fold or greater sensitization. All genes were tested with at least 4 siRNAs from Qiagen (Q). Many genes were characterized with 3 additional siRNAs from Ambion (A). The percent of tested siRNAs yielding a 2-fold or greater sensitization is listed for each gene.
Authors: Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D. Pfister, Philip M. Reaper, Christopher S. Barnes, Julie Jones, Peter Charlton, John R. Pollard, Joel Morris, James H. Doroshow, Yves Pommier
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361896083