Supplemental Figure S2 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure S2. Candidates with a majority of siRNAs inducing a > 4- fold shift in CPT EC50 (minimum of 7 siRNAs tested; left Qiagen siRNAs; right Ambion). Corresponding catalog numbers are listed in chart legends.
Authors: Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D. Pfister, Philip M. Reaper, Christopher S. Barnes, Julie Jones, Peter Charlton, John R. Pollard, Joel Morris, James H. Doroshow, Yves Pommier
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361896226