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Supplementary Methods, Supplementary Figure Legends, Supplementary Table, Supplementary Figures 1 through 7 from Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1

Year: 2023
Type: supplementary-materials
Abstract: Supplementary Methods Supplementary Reference Supplementary Figure Legends Supplementary Table Supplementary Figures Suppl Fig 1. Effect of DDR1 knockdown on internalization of alexa-647 labeled RG7787 Fig S2. Effect of DDR1 knockdown on mesothelin expression Fig S3. KB or A431/H9 cells were transfected with control siRNA or DDR1 siRNAs Fig S4. Effect of collagen I on DDR1 kinase activation in A) A431/H9 and B) KLM1 Fig S5. Nilotinib enhances cytotoxicity of RG7787 Fig S6. Combination of 7rh enhances cytotoxicity of native PE and HB21 Fig S7. 7rh inhibits DDR1 phosphorylation in A431/H9 tumors Table S1. siRNA and primer sequences used in this study
DOI: 10.1158/0008-5472.22411323
Authors: Fatima Ali-Rahmani, David J. FitzGerald, Scott Martin, Paresma Patel, Marco Prunotto, Pinar Ormanoglu, Craig Thomas, Ira Pastan
Institutions: National Cancer Institute, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Genentech, National Center for Advancing Translational Sciences, F. Hoffmann-La Roche AG
Language: English
Subfield: Immunology
Open Access status: gold
OpenAlex ID: W4361896784
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