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Supplementary Figures S1-S5 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1

Year: 2023

Type: supplementary-materials

Abstract: Overview of the screening strategy in haploid cells (S1); Correlation between ABCB1 and SMARCB1 mRNA expression levels across multiple human cancers represented in the TCGA database (S2); Correlation between SMARCB1 expression and doxorubicin resistance across multiple human cancers represented in the TCGA database (S3); SMARCB1 loss leads to ABCB1 upregulation, drug resistance and reduced Dox accumulation (S4); Hierarchical clustering reveals multiple classes of genes that are differentially expressed in WT Hap1 cells compared to Hap1 cells lacking SMARCB1 (S5).

DOI: 10.1158/0008-5472.22412193.v1

Authors: Ramin Dubey, Andres M. Lebensohn, Zahra Bahrami-Nejad, Caleb Marceau, Magali Champion, Olivier Gevaert, Branimir I. Sikic, Jan E. Carette, Rajat Rohatgi

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361896899

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