Supplementary Figures S1-S9 from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
Year: 2023
Type: supplementary-materials
Abstract: Figure S1, showing that lower miR-193b expression is associated with poor distant recurrence-free survival. Figure S2, showing the effects of miR-193b and miR-365 on liposarcoma cell growth. Figure S3, showing the effects of forced expression of miR-193b on the transcriptome and proteome in liposarcoma cells and selected gene ontology terms enriched among miR-193b targets. Figure S4, showing that CRKL affects cell proliferation, apoptosis, and expression of cell cycle regulators. Figure S5, showing that FAK affects cell proliferation and apoptosis. Figure S6, showing that miR-193b induces loss of mitochondrial membrane potential. Figure S7:, showing that knockdown of MSRA increases ROS levels and protein oxidation. Figure S8, showing hypermethylation of the miR-193b promoter and expression of DNMT1 in liposarcoma. Figure S9, showing the tumor suppressive activity of miR-193b in vivo.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361898135